Windows Xp Drive Access

Can anyone help me with this one. When I click on a drive folder that contains around 20 gigs of files, the drive in question is accessing for up to ten minutes, therefore if I try to open a file I have to wait until something else has finished. This problem only happens on one drive partition, the other partition is fine.
Can't work it out, have defragged, not helped.
 
are u usin the same file structure on both drives?.... another thing to check is that the partitions rnt overlapping...that can cause all kindsa problems
 
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