You don't need to play and store it...just make your settings and Render Selection/Process in place.
Sounds strange to me it doesn't work, are you sure?
Again, what kind of noise are you trying to clean?
Did you set up sliders correctly for the noise you r trying to clean?
This effect is very goog to clean LP/MC rustling background noise, and works fine for me, often it depends on the song you r cleaning, maybe the song ain't that noisy and you can't hear the difference
Try to play a bit with other songs to ensure you'r using the plug correctly
You should hear the difference ! This plugs restored many bootlegs for me !