I didn't think of that one....
The "OLD" standard, of having a large (AT) Keyboard port, 2 serials, 1 parallel and maybe an optional PS/2 mouse port, though as all items other than the keybors were on plates or extra punch-outs with header cables, they could be left unconnected.
This was then replaced by the ATX interpreatation -
PS/2 Keyboard, PS/2 mouse, 1 or 2 serials, 1 parallel, 2 USB on plate - and finally the push to "legacy free"
As I understand "legacy free", it means NO round keyboard and mouse sockets, NO serials, NO parallel and NO floppy (not certain of the last).
Unless it's fully legacy-free, there should be ONE serial port at least, and if already occupied by a serial mouse, cheapest way out would be to replace the mouse with a USB or PS/2 version. Also some mice had PS/2 to Serial adapters, while the current "combo" mouse is normally a USB to PS/2