The CIH virus is the one that can zap the BIOS, or messing up a flash can do it too (wrong flash, or interrupting).
Some older boards had a protected bootblock, which could be used to reflash "blind" using a prepared floppy, but NOT an easy procedure.
Another HIGH RISK procedure if you have another identical / compatible motherboard and the BIOS is socketed - is the HOTSWAP.
The hotswap procedure requires:
1. A spare flash chip of the correct type (or the erased/misflashed one pulled from the nonfunctional board)
2. A suitable "donor" board
3. A flash that will load on the donor
4. Good nerves and a steady hand
Pre-loosen the donor's flash chip, by removing and then half-inserting (you may like to stick something to it to make the risky bit easier)
The system MUST be operating with BIOS SHADOW.
Start up, on a boot floppy prepared for flashing.
Pull the flash chip, and replace with the target (YES, with the power ON).
Now complete the flash procedure.
If it worked, you now have two flash chips loaded for that board.
IF IT FAILED, YOU MAY HAVE KILLED THE DONOR, AND/OR ONE OR BOTH FLASH CHIPS.
The only thing I can add, - is a friend did it to replace an EPROM with a FLASH, in a board which could take a flash chip, and needed it to be able to update - and it worked.
The procedure is HIGH RISK, but according to other hearsay, is amazingly successful if done well.
It's possible that it may help if the +5v and GND pins of the chip are pushed slightly forward, and the alignment mus be set so that all pins go in without fumbling.
If in doubt - DON'T DO IT!